Current reviews in clinical and experimental pharmacology, 16(2), 162167
Payman or Dr
Its potential molecular features include elevated urinary ferritin, increased ACSL4 expression, reduced GPX4 levels, increased MDA and ROS, and activation of ALOX15 and HMOX1 (Wu et al., 2023
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GPX1-4 and GPX6 use selenocysteine as the active center to catalyze the reduction of H 2 O 2 or organic hydroperoxides to water or corresponding alcohols, thereby reducing their toxicity and maintaining redox balance