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Retatrutide produced substantial reductions in liver fat up to 82.4% at 24 weeks with higher doses in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), as well as significant reductions in the urine albumin-to-creatinine ratio (UACR) compared to placebo in post-hoc analyses, suggesting a potential renal-protective effect

The WHO explicitly acknowledges that we do not yet have strong long-term data on lifelong use of these medications, cautioned Jenkinson

Verdict at a Glance CagriSema and retatrutide represent two fundamentally different approaches to next-generation obesity treatment