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Clinical trials demonstrated that semaglutide achieved superior HbA1c reductions compared to earlier GLP-1 receptor agonists, with the SUSTAIN clinical trial programme showing mean HbA1c reductions of 1.51.8% (approximately 1620 mmol/mol) from baseline

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Tirzepatide demonstrated that adding GIP activation to GLP-1 agonism produced meaningfully better outcomes than GLP-1 alone

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