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TABLE 2 provides a summary of key information from PIONEER 1-8

Early Discoveries, With More to Come So far, GLP-1s, first approved 20 years ago for type 2 diabetes and later obesity, have shown potential in treating a surprisingly wide range of conditions, such as heart disease, Parkinsons, Alzheimers, sleep apnea, and liver disease

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Alogliptin after acute coronary syndrome in patients with type 2 diabetes

The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells

Moreover, single-pathway interventions often require higher therapeutic doses, increasing the risk of adverse effects