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Theyve been drinking coffee but minimal water, skipping breakfast because theyre not hungry, and have recently cut out most packaged foods, inadvertently eliminating most of their dietary sodium

Others have better luck starting low and slow with Semaglutide

Projected Timeline (Estimates, Not Confirmed) Phase 3 completion: Most TRIUMPH trials completing throughout 2026 NDA submission to FDA: Estimated late 2026 (depends on results across the full program) FDA review period: Typically 10-12 months for a standard review Approval decision: Estimated 2027, possibly earlier if Lilly seeks priority review Commercial availability (pharmacies): Several months after approval for manufacturing scale-up GlobalData, a pharmaceutical analytics firm, projects a 2027 approval with forecasted annual sales reaching $15.6 billion by 2031

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Eli Lilly now sells Zepbound, its tirzepatide obesity drug, directly to consumers for $349 or $499 per month, depending on the dose

The dual mechanism explains why tirzepatide outperforms semaglutide, which activates only GLP-1