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Ileal release of glucagon-like peptide-1 (GLP-1)
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In clinical trials, individuals taking semaglutide noticed weight loss as early as the 4-week mark, even at lower starting doses (e.g., 0.25 mg per week)
Evidence for whether GLP-1 receptor agonists can penetrate the BBB remains limited as it has been argued that brain capillary binding or sequestration may not have been accounted for [29]
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