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(2011) 13:e11
An oral PGDHi is already in clinical trials with the goal of treating age-related muscle loss
This is administered as a weekly subcutaneous injection, the same as standard semaglutide injections
However, 2026 will be a turning point: as semaglutide loses patent protection in major global markets, such as China, Canada, and Brazil, and with liraglutide already off-patent in the US, the growth of generics is expected to drive down costs and improve global equity
Zealand Pharma and Boehringer Ingelheim are working on two dual agonists dapiglutide and survodutide (BI 456906) that are in phase 2 trials for weight loss
Most reported side effects of these peptides in studied doses are mild (injection-site irritation, transient sleep or vivid dreams, headaches), but longterm, largescale human safety dataespecially for longevity useremain limited
