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Researchers identified a hit, a drug that was developed nearly a decade ago

Legette et al., 2014), mimicking endogenous estrogens

Research has characterised MT-IIs anorectic effects as MC4R-mediated through hypothalamic PVN and arcuate nucleus mechanisms , documenting food intake suppression kinetics, NPY/AgRP pathway suppression, and melanocortin pathway activation markers in hypothalamic tissue following MT-II treatment

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