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Results: Administration of high dose MTX (5 mg/kg) today 4 produced a significant decrease in hepatic glutathione (GSH) levels and a significant increase in ALT and AST liver enzymes, hepatic malondialdehyde (MDA), tumor suppressor protein (p53), interleukin 6, interleukin 1 levels compared to the control group

Curdy C, Kalia YN, Guy RH

Multicenter trials would provide sufficient power to detect clinically meaningful effects and assess safety across diverse patient populations

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Conditional Add-Ons NAD+ is the primary metabolic add-on considered for GLOW