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Mechanistically it adds steric and electrostatic bulk at the same end of the molecule the binding proteins engage, deepening the reduction in affinity beyond what the single substitution achieves alone
1992 Feb 15;282 ( Pt 1)(Pt 1):91-7
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
It is thought that NADPH prevents the formation of the inactive form of catalase (Compound II) and that it increases the rate of removal of this inactive form [45, 53, 55, 56]
Basic Clin Pharmacol Toxicol 126:8691
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