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Potential Risks, Considerations, and Safety Profile Tirzepatide carries FDA-labeled risks including pancreatitis (rare at 0.1-0.2% incidence), gallbladder complications, and potential C-cell proliferation based on animal modelsthough human thyroid safety data remains limited beyond 3-year trials

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In the SURMOUNT-1 trial, those on 15 mg of tirzepatide lost an average of 20.9% over 72 weeks