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To confirm whether an increase in UCK2 activity as a result of pyrimidine stress was the driving force behind mitochondrial biogenesis signalling, we knocked down UCK2 in cells using siRNA (Fig

Mitochondria are the major source of reactive oxygen species (ROS) in cells

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When someone arrives with a significant deficiency, their stores are low, their red blood cells may be enlarged (macrocytosis), and, in longstanding cases, nerve function can be affected

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