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European Journal of Endocrinology (1998) 5
Per Section 201 of the Act (21 U.S.C
This fat-to-lean ratio is comparable to what has been reported for semaglutide (around 39% lean in STEP 1) and tirzepatide (around 25-33% lean in SURMOUNT-1) retatrutide does not appear to preserve muscle better or worse than the existing GLP-1-based drugs in this dataset, though the obesity-only Phase 3 population has not yet been measured
The connection to cancer survivorship comes from applying these findings about metabolic health and visceral fat to a population that often benefits from improving cardiometabolic health
For comparison, semaglutide hair loss (active ingredient in Wegovy) was recorded in adult weight-management trials at ~3% on treatment versus ~1% on placebo, and ~4% in adolescents
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