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Notably, we observed no lung cancer related deaths in Kras G12D ;Ddx3x fl/fl and only a limited number in Kras G12D

The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations

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doi: 10.1038/jcbfm.2009.73 13

Unintended Weight Loss Despite having a normal appetite or even an increased appetite, you may experience unexplained weight loss