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Another study examined the effects of six weeks of therapy in older men

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This seems like a backwards way to try to legitimize and legalize these unapproved peptides

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Treatments were vehicle (V), CagriSema (CS, 2 + 2 nmol/kg), and calorie-restricted to match the weight of the CS rats (weight matched, WM)

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GHK-Cu is a naturally occurring peptide made of glycine, histidine, and lysine bound to copper

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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

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