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Figure 1 Biological Function of Lipoic Acid Quenching reactive oxygen species Based on the definition of an antioxidant provided by Halliwell and Gutteridge as being any substance that when present at low concentrations compared to those of an oxidizable substrate significantly delays or prevents oxidation of that substrate, LA has several unique characteristics among other natural antioxidants to fulfill this criterion (Petersen Shay et al., 2008)
Van Bladeren PJ (ed)
Meanwhile, it inhibits NLRP3 inflammasome-related immune inflammation and pyroptosis of PASMCs, improving vascular remodeling in PH (Tang et al., 2025)
It is low in calories and boasts a high concentration of vitamins, minerals, and antioxidants that may offer numerous health benefits, such as helping lower blood pressure and cholesterol and helping support immunity.
This manifests as AKI, requiring renal replacement therapy in severe cases and significantly increasing mortality risk (97)
