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Groups with limited or no safety data Published human trials with AOD-9604 enrolled adults with obesity (BMI 30-45 kg/m^2), generally aged 18-65

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This controlled copper transport serves as cofactor for critical enzymes including: Lysyl oxidase: Essential for collagen and elastin cross-linking Lysyl hydroxylase: Required for proper collagen synthesis Superoxide dismutase: Provides antioxidant defense mechanisms Cytochrome c oxidase: Powers cellular respiration Tyrosinase: Facilitates melanin production The peptide can readily obtain Cu from plasma albumin, functioning bidirectionally to transport copper into or out of cells based on cellular requirements

Zhu, H., Jia, Z., Misra, H