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The underlying driver is chronic inflammationspecifically, dysregulated immune signaling involving TNF-, interleukins (IL-17, IL-23), and NF-B pathways

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The predominant oxylipins include AA derivatives like prostaglandins, thromboxanes, and leukotrienes (60)

The Endocrine Society position on testosterone therapy emphasizes the importance of comprehensive approaches to mens hormonal health, which often includes considering growth factors like IGF-1

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