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High blood sugar can contribute to weight gain and type 2 diabetes
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Furthermore, incretin-based therapies can also improve mitochondrial function and reduce apoptosis by increasing anti-apoptotic protein Bcl-2 expression and lowering pro-apoptotic BAX signaling, thereby promoting neuronal survival in dopaminergic cell lines ( GLP-1 receptor agonists (e.g., exenatide, liraglutide, lixisenatide) and dual GLP-1/GIP agonists (e.g., tirzepatide) have been also reported to reduce microglial and astrocytic hyperactivation and suppress the release of inflammatory mediators such as TNF-, IL-1, and NF-B
The change in metabolism could be compared between the pre and post-NAC scans and compared to the control group scans
Within five years of diagnosis, approximately 20% of UC patients require hospitalization and 7% undergo colectomy, highlighting the persistent morbidity associated with this condition (28, 29)
NAION is the most common optic neuropathy in adults over 50, caused by hypoperfusion of short posterior ciliary arteries supplying the optic nerve, inducing swelling that creates compartment syndrome compressing neighboring axons, resulting in ganglion cell death
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