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Macrophages and tissue injury: agents of defense or destruction
Therapeutic strategies aimed at restoring microbial homeostasis, reinforcing gut barrier integrity, or modulating innate immune activation such as probiotics, prebiotics, dietary interventions, fecal microbiota transplantation, and TLR-targeted agents hold promise for disease modification
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N-acetylcysteine, an efficient thiol antioxidant and GSH precursor, was able to inhibit ATG by impeding the lipidation process of LC3 mediated by ATG4, the activity of which is modulated by hydrogen peroxide (Scherz-Shouval et al., 2007)
