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These stimuli drive the accumulation of pro-apoptotic B-cell lymphoma 2 (Bcl-2) proteins on the outer mitochondrial membrane (OMM), thereby enhancing OMM permeabilization (102, 103)

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doi: 10.1080/10717544.2022.2039804 125 SurapaneniSKBashirSTikooK

Microglial ferroptosis can activate neurotoxic astrocytes through pro-inflammatory signaling, and ferroptosis-related genes such as ALOX5/15 are highly enriched in microglia, yet this study does not establish whether ferroptosis is upstream in the cascade involving mitochondrial complex IV defects, oxidative stress, and neuroinflammation

By repositioning studio pedagogy as a transformative learning environment, this study contributes to the debate on how planning education can better respond to contemporary socio-spatial challenges