PolA2 (G583R) mutation led to localize in the cytoplasm instead of the nucleus, which inhibits DNA replication in cancer cells (e.g., non-small cell lung cancer (NSCLC) and makes them sensitive to chemotherapy (e.g., Gemcitabine) (Mah et al., 2014)
This ensures faster absorption, especially in people with vitamin B12 deficiency
Regardless of which direction you're transitioning, keep your prescribing provider informed about the switch
The combination of delayed gastric emptying and high sulfur intake creates conditions that may increase hydrogen sulfide production
Research is ongoing to evaluate its safety and efficacy in children, but as of now, it is primarily used for managing type 2 diabetes in adults
Check with your specific insurance provider