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Functioning independently of its canonical unfolded protein response role, the endoplasmic reticulum-resident protein IRE1 governs ferroptotic susceptibility through an evolutionarily conserved mechanism wherein its endoribonuclease activity degrades transcripts encoding glutathione biosynthesis factors GCLC and SLC7A11, rendering IRE1-deficient cells resistant while overexpressing cells hyper-sensitive to this death pathway (55)

Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma

When it comes to anti-doping and clean sport we are in serious trouble when giant retailers like Amazon are once again some of the largest purveyors of performance enhancing drugs on earth

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In: Ferri FF, ed

Fatty acids are utilized as an energy substrate in all tissues except the brain