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As orthopaedic surgeons, we must take a holistic approach to patient care, considering comorbidities and medications to optimize surgical outcomes
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Moving forward, the redox status and activity of BiP will be of particular interest, given its roles in protein folding, ERAD, protein translocation, and UPR signaling (Pobre, Poet, & Hendershot, 2019), and the fact that oxidative modifications can alter the nature of its associations with nascent proteins (J
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