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People taking GLP-1 medications commonly report reduced food cravings, less emotional eating, and a quieting of the constant mental preoccupation with food that researchers call "food noise." Animal studies have also shown that GLP-1 receptor activation reduces the rewarding properties of high-calorie food in the brain findings confirmed in a landmark randomized, placebo-controlled neuroimaging study in humans ( van Bloemendaal et al., Diabetes, 2014 )
Indeed, it has been suggested that certain cytokines that are upregulated during HIV infection have the capacity to induce the production of -MSH by oral melanocytes and keratinocytes and to mediate the upregulation of expression of MC1R by melanocytes, resulting in increased melanin production
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Less common than nausea or constipation, but reported by some patients particularly in the early weeks
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