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10.1371/journal.pone.0077284 15 EgeciogluE.EngelJ

Optimal doses range from 0.5mg to 1.2mg depending on subject body composition, receptor density, and prior exposure to melanocortin agonists

Ma J, Jiang Q, Xu J, Sun Q, Qiao Y, Chen W, et al

"If [the drug companies are] effective in proving that the side effects are moderate and that the overall benefit is sustained and is good, why would the government not cover it

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Whether this is due to cumulative immune modulation or other factors is unclear