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The model predicted that for 10-hour-long toxicologically relevant doxorubicin (50 M) simulations, the duration of the exposure is more important than concentration with respect to overwhelming glutathione metabolism
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Given that cellular senescence is now recognized as one of the primary pillars of biological aging, this third mechanism elevates MOTS-c from a metabolic peptide to a potential geroscience intervention
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In patients with mutations in the C9ORF72 gene, the production of harmful dipeptide repeat proteins further disrupts communication between the nucleus and cytoplasm, impairing cell function
Additional secretion of growth hormone not only contributes to muscle growth but also improves cell communication through activated biochemical pathways essential for further linear development
