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However, GSH has an overall negative charge at physiological pH, and mitochondria also exhibit an enormous negative membrane potential [57, 58]

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Thereinto, the antioxidant effect of CoQ10 may be partially attributed to activating the GSH system

Collectively, abnormal expression or activity of these mitochondrial transporters in tumor cells can affect mitochondrial function, metabolic reprogramming, and oxidative stress, impacting tumor expansion and progression