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The ratio of reduced (GSH) and oxidized (GSSG) glutathione is an important measure of a cells ability to maintain redox homeostasis

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However, SFN did not achieve the same effect in NRF2-deficient mice

To test whether HNF4 confers sensitivity of liver tumors to methionine restriction in vivo, 5 10 6 siNeg and siHNF4 HepG2 cells were injected subcutaneously into each flank of female NU/J mice (#002019, Jackson Laboratory)

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