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The increase in lactate that we detected points towards a defect in oxidative energy metabolism, but this conclusion must be treated cautiously given the difficulty of measuring lactate in the presence of the much larger and broader macromolecule (MM) resonance at ~1.35 ppm, with the lactate signal being a small shoulder on that peak (Fig
Nrf2-dependent antioxidant response mediated the protective effect of tanshinone IIA on doxorubicin-induced cardiotoxicity
Furthermore, impaired leptin regulation in the liver disrupts satiety signals, leading to overeating and creating a vicious cycle
Broader population-level metabolic improvements could influence: Food industry Greatly reduced food intake as appetite declines may restructure agriculture, manufacturing, restaurants, grocery stores and more
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