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In contrast, PD-linked missense mutations destabilize Syn tetramers, reduce solubility, promote cytoplasmic inclusions, and induce neurotoxicity 67

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doi:10.1073/pnas.71.10.3879

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Recent studies in animal models and human subjects have demonstrated a close relationship between the gut microbiota and atherosclerosis, especially the gut metabolite TMAO (1315)