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Off-label use simply means a provider is using a substance for a purpose other than its original intention, based on professional judgment and clinical evidence

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Doing so can increase the risk of side effects like low blood sugar (especially if combined with other diabetes medications) or gastrointestinal upset

The primary reference is Raun and colleagues (Eur J Endocrinol, 1998), the paper that introduced the molecule and established the property it is known for

World J Gastroenterol (2014) 20:145069

doi:10.1016/j.ijcard.2022.05.056 Tonhajzerova I, Sekaninova N, Bona Olexova L, Visnovcova Z