glp 1 agonist small molecule Small-molecule agonists activate the Ga s pathway and inhibit hGLP-1R GLP-1R agonist 2 | GLP-1R

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doi: 10.1056/NEJMoa2108269 86 HernandezAFGreenJBJanmohamedSDAgostinoRBGrangerCBJonesNPet al

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Key findings include dose-dependent GH release lasting up to 6 days with a single injection, 2 to 10-fold increases in GH levels, and significant IGF-1 elevation sustained over weeks of therapy

GLP-1s are serious medications with certain potential toxicities for some patients, including pancreatitis, thyroid cancer, and very rarely, but now officially acknowledged in the case of Wegovy blindness, caused by a condition called non-arteritic anterior ischemic optic neuropathy (NAION)

The overall discontinuation rate due to adverse events was approximately 10%, which compares favorably to most compounds in this class