Generalizability of treatment outcome prediction across antidepressant treatment trials in depression
We extracted ten pre-specified variables: (1) comorbidity prevalence, (2) mean age, (3) gender ratio, (4) publication year, (5) EQ-5D version (3L/5L), (6) region (Europe, Americas, Asia, Oceania, Middle East), (7) sampling method, (8) administration mode, (9) survey venue, and (10) language
doi:10.1007/s00253-024-13007-7 VERONICA O
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A FAIR Health analysis found a nearly 600% rise in patients using GLP-1s for weight loss over six years, reaching over 2% of the population ( [2] ), even as total GLP-1 usage (for any indication) approached 4% of Americans (driven roughly half by weight-loss vs diabetes) ( [2] )
GH and IGF-1 operate via generalized anabolic stimulation and mitogenesis, whereas BPC-157 appears to favor modulation of the tissue microenvironment (local angiogenesis, controlled inflammation, endothelial stabilization)