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We used two strains of transgenic mice which replicate features of ALS, an optimised SOD1 G93A transgenic model 23 and a TDP-43 Q331K transgenic line 24

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When glutathione pathways are disrupted, patients experience a cascade of downstream effects, from mitochondrial damage and severe post-exertional malaise (PEM) to impaired liver detoxification and histamine intolerance