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GLP-1 is a secreted hormone with multiple effects upon the intestine (gastric motility), pancreas (glucose dependent insulin release) and hypothalamic pituitary axis (modulates LH, THS, CRH, ocytocin and vasopressin secretion)

Key distinctions between these agents include: Receptor breadth : Retatrutide's inclusion of GCGR agonism is unique among agents in advanced clinical development Hepatic effects : The glucagon component is under investigation for potential benefit in metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD)

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