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The resulting network, derived from the 642 DEGs, comprised 328 nodes (representing 328 of the DEGs) and 764 edges, forming its largest connected component (Fig
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Recently, the newly developed drug tirzepatide, which targets both the GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, was introduced to the market to treat type 2 diabetes and obesity in 2022 and 2023, respectively (Table 1)
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Mice received once-daily sham injections with isotonic saline from 3 days before study start and were randomized to treatments on the basis of body weight at the day of study start
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