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And they are engineered to resist the enzymes that normally break down natural GLP-1 within minutes, allowing the drug to maintain receptor activation for days rather than minutes

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10.1016/j.avsg.2017.06.131 Ann Vasc Surg

Undoubtedly, drug-induced nephrotoxicity is a major cause of renal impairments and a potential impediment to the research and development of drugs, requiring more reliable and early diagnosis to avoid potentially fatal chronic conditions