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The extracellular L-cysteine/L-cystine redox balance, and thus the synthesis of GSH, is finely regulated by the intracellular conversion of L-cystine into L-cysteine (10), and its impairment is related to oxidative stress and other pathological disorders
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Topical applications are used primarily for skin benefits but may not significantly affect overall glutathione levels
p53 can reduce the expression levels of SLC7A11 by directly inhibiting its transcription, which reduces cysteine uptake and GSH synthesis, thereby impairing GPX4 activity and increasing cellular sensitivity to ferroptosis (73,74)
Like glycolic acid, it can: Lactic acid also acts as a humectant (like hyaluronic acid)
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