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Frontiers in Immunology
Under physiological cystine supplementation, excess heme exposure suppresses the TSS pathway and leads to elevated ferroptosis
Because adequate, well-controlled studies in pregnant individuals are lacking, use should be limited to circumstances in which the potential maternal benefit clearly outweighs theoretical fetal risk-such as treatment of documented systemic carnitine deficiency
If the vial needs to be out of the refrigerator temporarily for administration, brief periods at room temperature are acceptable
After the initial course, maintenance sessions every 2 weeks help sustain the improvements
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