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In the SURPASS studies, the reduction of the systolic blood pressure was primarily mediated through weight loss [40, 54, 55]

Strength training is likewise mixed, with 21 percent of GLP-1 users having increased the time spent on strength training, 17 percent having decreased it and 41 percent having never done it at all

Meal structure: Eating smaller, more frequent meals (3 meals and 1 to 2 snacks) can help manage nausea and ensure adequate nutrient intake

The simulations are not intended to estimate a new causal effect, but to illustrate how changes in persistence and care contextwithin plausible ranges documented in RWEwould alter the realized effectiveness of semaglutide at the population level

PMCID: PMC5551541