1997 May-Oct;91(3-5):113-22
rare reactions include mild nausea and headache
Published pharmaceutical manufacturing standards exist specifically because the margin between "looks clean" and "is sterile" is the difference between a safe injection and a fever, abscess, or systemic infection
A possible reason could be that these three enzymes are related to maintenance of adequate reduced glutathione levels, whereas GPx1 is involved in its direct consumption
doi:10.1159/000494783 Bazzano G, DElia JA, Olson RE
Fraternale et al., 2017), as well as conferring protection against oxidative stress caused by microbial, parasitic and viral infections such as SARS-CoV-2 that causes COVID-19 disease (Morris et al., 2013