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High doses of semaglutide (7.2 mg) caused the side effect in 22.9% of participants in experimental trials
Cellular signaling mechanisms
At the end, Pfizer won the bidding war for Metsera
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After 56 weeks: Placebo group lost 1.6% of body weight Starting dose (3.75/23 mg) group lost 5.1% of body weight Top dose (15/92 mg) group lost 10.9% of body weight Beyond weight loss, the CONQUER trial showed significant improvements in blood pressure, waist circumference, lipid profiles, glycemic parameters, and inflammatory biomarkers compared to placebo
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