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The switch from sulphonylurea is most likely due to the need to replace drugs associated to a greater risk of hypoglycemia and weight gain [5] with a more effective and safer alternative, which allows oral administration to be maintained [28, 32]

Rybelsus may show slightly faster onset with effects visible by week 4, while Trulicity at higher doses (3-4.5mg) can achieve reductions up to 1.8%

doi: 10.1016/j.molmet.2017.08.010 113 DemmelVSandberg-SchaalAJacobsenJBGolorGPetterssonJFlintA

however, the review noted that most included studies focused on patients with diabetes rather than those with obesity

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