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Initially, the neuroprotection of GLP-1RAs was tested in in vivo models of diabetes
Severe cases may require hospitalization or surgery
These results suggest that specific modification of peptide is equally significant to sequence optimization in terms of demonstration of a desired polypharmacology of a unimolecular dual or triple agonist
doi: 10.1093/intimm/dxg027 7 CollierA.SmallM.WilsonR.BradleyH.ThomsonJ
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Its investigation included seeking advice from an independent expert group, the Advisory Committee on Medicines, which in June reported that there was insufficient evidence of a causal link between the medicines and suicidal ideation or behaviours
