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reported elevated GLP-1 levels in individuals with sarcopenia, and in vitro analyses further suggest that chronic and high exposure to GLP-1 may impair normal muscle cell differentiation and function by disrupting intracellular energy transporter (GLUT-4) translocation and mitochondrial function [88]

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However, when GLP-1 receptor agonists are used in combination with insulin or sulphonylureas, the risk of hypoglycaemia increases, and dose reduction of these agents may be necessary

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Building off this research, a new study offers further evidence of semaglutide and lowered major cardiac event risk, regardless of how much weight a person loses while taking the GLP-1 medication