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This was supported by a recent metanalysis in which, twenty- two randomized controlled trials involving 61,412 patients who were either T2DM patients with or without cardiovascular disease or patients with cardiovascular disease alone, were included in the meta-analysis, and results have shown the diastolic function according to echocardiography was significantly improved by GLP-1R agonists [88]

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FIGURE 2 3.3 Secondary outcomes 3.3.1 The comparison of renal function indicators between two groups According to statistical results, it showed that mean SD of BUN after treatment were 14.8 5.9,11.9 3.8 in RG group and RG + CHF group respectively