Diabetologia 68 , 16801695 (2025)
Type 2 diabetes was identified in 3.4% of the group
Novo has since launched a broad late-stage program for CagriSema, including the Phase III trials REDEFINE 1, which is assessing its efficacy as a weight loss therapy, and REDEFINE 2, designed to include type 2 diabetes patients with excess body weight
Novo Nordisk spokesperson Allison Scheider says the company takes all reports about new side effects "very seriously," but added that this class of drugs has been used for more than 15 years
This sustained elevation in metabolic rate helps prevent the adaptive thermogenesis (metabolic slowdown) that typically accompanies significant weight loss and contributes to weight regain
For most patients, these changes are temporary and manageable