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Human trials of GLP-1R agonists in Parkinson disease have shown promising signals

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What this data doesn't tell us: whether NNMT suppression sustained beyond 12 weeks alters NAD+ metabolism in ways that affect mitochondrial function, whether methylation pathway compensation occurs over longer timescales, or whether adipose tissue remodeling continues linearly or plateaus

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However, serum levels were higher in people prescribed valproate