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Bottom Line Low testosterone can contribute significantly to weight gain by reducing muscle mass, slowing metabolism, increasing fat storage, and lowering energy and motivation

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4 C,E ), consistent with the glutathione cycle being able to compensate for decreased availability of glutamine, an established source of glutamate neurotransmitter

This is because there is a competitive need for glutathione (GSH) to be used: 1) to clear H 2 O 2 , a byproduct of oxidative stress [10] , and, 2) to enable the detoxification of formaldehyde [17]

The second is albumin-mediated half-life extension